Recognizing the crucial role of science, technology, and innovation (STI) in achieving the Sustainable Development Goals (SDGs), this report is set within the broader context of the European Commission’s global and regional initiatives, underscoring the commitment to the Global Gateway initiative. It forms part of a collaborative endeavour by the Joint Research Centre (JRC) and the Directorate-General for International Partnerships (DG INTPA) of the European Commission, focusing on five African countries. Within this framework, the report focuses on Seychelles, exploring STI’s role in addressing the country’s critical sustainability challenges, particularly in enhancing energy efficiency and integrating renewable energy sources. The objective is to boost energy efficiency and renewable energy uptake by formulating an STI for SDGs Roadmap through participatory and co-creative approaches. The methodology involves comprehensive desk research, stakeholder workshops, interviews, and surveys to collect insights from public and private sectors, NGOs, and academia. Findings highlight Seychelles’ significant reliance on fossil fuels, inefficient electricity production, and underutilized renewable energy potential. Key policy recommendations include strengthening STI governance, enhancing human capital, and fostering eco-innovation through focused R&D. The report’s originality lies in its tailored approach to leveraging STI for reinforcing Seychelles’ energy resilience and sustainability, which provides a well-structured portfolio of STI investments specifically tailored to Seychelles’ sustainability challenges and offers a valuable framework for other countries facing similar sustainability issues.